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Asim Niyaz, Emel Ergene (Eskisehir Technical University, Turkiye)
Visual representation of both the open and closed conformations of ADAM10. While the extracellular region of ADAM10, a single-pass transmembrane protein, has been experimentally resolved (PDB IDs: 6BE6, 8ESV), its transmembrane and cytosolic domains are yet to be determined. A comprehensive model of the full-length active enzyme is essential for studying its interactions with substrates. The model presented here is derived from an ongoing project, generated through a computational workflow involving several Rosetta protocols.