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Jyothish Bhai, Sanjay Boddu, Imran Salam, Dan Sheppard, Steve Trevanion, Andrea Winterbottom, Andy Yates, Paul Flicek (European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom)
The Ensembl project (www.ensembl.org) aims to disseminate aggregated genomic annotation, including graphical views. High-throughput sequencing projects and annotation efforts such as though conducted within the Ensembl project are creating immense volumes of such data which are a challenge to efficiently represent and for a user to explore. Novel navigation approaches often require a lower latency between user input and response than can be practically achieved with typical network latencies. Dynamic, smart-client approaches can also allow data to be retrieved in the background, incrementally, reducing computational load and latency. Both these drivers push toward client-based models. WebGL is a technology which allows a significant portion of the workload to be shifted to the GPU. WebGL’s compact, efficiency-oriented model is also ideal for very complex scenes. Ensembl has switched to such a model for its 2020 redesign. This is implemented in WASM, coupled with ReactJS for the website framework.