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Renaud Chabrier (Institut Curie)
This image is inspired by the work of Philippe Chavrier at Institut Curie (Paris, France). Internal trafficking allows this cancer cell to target specific extracellular fibrils of the collagen matrix for proteolic degradation. This degradation facilitates cell body and nuclear movement, while other fibrils are spared and allow traction force generation during constricted migration in a 3D environment.