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Yordan Hodzhev1, Borislava Tsafarova1, Vladimir Tolchkov1, Nikolay Yanev2, Vania Youroukova2, Silvia Ivanova2, Dimitar Kostadinov2, Stefan Panaiotov1 (1National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria 2Department of Pulmonary Diseases, Medical University, Sofia, Bulgaria)
There is a growing body of studies linking the normal host-microbiome to lung carcinogenesis. Lung tumors contain a significant number of microbial taxa, which differ quantitatively and qualitatively from the composition of the normal tissue microflora. Some of these microorganisms are directly involved in the process of carcinogenesis. Carcinoma is considered a mini habitat with specific, very limited, growth conditions. Normally, competition and immune response keep pathogenic microorganisms and cell malignification at a very low level. However, external infection and/or immune system failure can facilitate microbiome dysbiosis and hence carcinogenesis. The combined study of blood and tissue microbiome changes and the dynamics of tumor growth allow to assess the contribution of the microbiome in tumorigenesis. This could identify the driving factors that govern pulmonary carcinogenesis and the switch of the normal lung tissue into malignant. This, in turn, will suggest new therapeutic approaches, which could be capable of slowing, stopping or reversing oncological processes. This study was supported by BNSF grant KP-06-DB/10 - 21.12.2019https://ncipd.org/index.php?option=com_k2&view=item&id=499:sectormicrobiom&Itemid=1097&lang=bg