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Yumi L. Briones, Nina Rosario L. Rojas, Fabian Antonio M. Dayrit, Armanda Jerome H. de Jesus Jr., Alexander T. Young (Ateneo de Manila University, Quezon City, Philippines; Institute of Environmental Science and Meteorology, Quezon City, Philippines)
Medicinal plants have long been used to boost our health and fight disease. But how do these plants work inside our cells? We designed a workflow to visualize the cellular action of a medicinal plant as a network. For this study, we looked at Momordica charantia (bitter gourd) in colorectal cancer. First, we predicted protein targets for the phytochemicals in M. charantia, a process known as reverse screening. We used this to build an interaction network, focusing on the colorectal cancer pathway. Using Cytoscape, we made a rich visualization that reflects plenty of useful information. Proteins are organized by cell location, phytochemical classes sorted by color, and other attributes (e.g. lipophilicity, bioavailability) shown with visual scales. In general, this workflow can be used to visualize the action of any medicinal plant in any disease. Resulting networks can be easily interpreted and used to inform future in vitro or in vivo experiments.