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Bang Wong, Aravind Subramanian, Josh Gould, Corey Flynn, Todd Golub, and the CMap team (Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA)
The Connectivity Map, a LINCS data generation and analysis center, generates a genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules and genomic perturbations. The Connectivity Map leverages pattern-matching algorithms to enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes. Here we present both an overview of the data generation process and a live demonstration of data analysis and visualization.