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Leonora Martínez-Nunez, Mary Munson (UMASS medical school. Worcester, Massachusetts. )
Internal membrane trafficking in yeast cells is regulated by the Exocyst complex. Which controls fusion of secretory vesicles at the plasma membrane to facilitate cellular growth, signaling, and division. The exocyst is a multisubunit tethering complex (MTCs) that “tether” two membranes together to facilitate SNARE-mediated membrane fusion (Sso1/2, Sec9 - T-SNAREs; Snc1/2 - V-SNARE). In coordination, a regulatory SM protein (Sec1) controls the SNARE-mediated membrane fusion.