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Chandan Sona and V Badireenath Konkimalla (National Institute of Science Education and Research, Institute of Physics Campus, Sachivalaya Marg, PO: Sainik School, Bhubaneswar - 751 005 India)
Kinases are vital enzymes that are involved in several signaling events in our biological system. Malfunctioning in these kinases has been indicated in diseases such as cancer, diabetes etc due to alteration in the signaling cascade. This makes kinase an important druggable target. Although there are several kinase inhibitors available in the market still the cure rates are rather low due to factors such as chemoresistance, selectivity, specificity, etc. The major challenge of specificity is due to the fact that there are about 518 human kinases with a conserved ATP binding pocket, an attractive site for drug targeting. Therefore, inorder to rationally design kinase inhibitors, an understanding of the different kinase structure and the interaction with ligands is required.