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Julian Heinrich, Michael Krone, Sean O'Donoghue, Daniel Weiskopf (CSIRO, Sydney, Australia; Visualization Research Center, Stuttgart, Germany; Garvan Institute of Medical Research, Sydney, Australia)
Intrinsically disordered regions (IDRs) in proteins are still not well understood, but are increasingly recognised as important in biological function and regulation, as well as in diseases. The presence of IDRs often confounds experimental structure determination, although they are present in many available 3D structures. Analysing and visualising such wide ranges of conformations is often difficult; our goal in this work is to improve this by augmenting traditional approaches (molecular graphics and principal-component analysis) with methods from human-computer interaction and information visualisation.