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Sigrid Knemeyer (19 Fairview Dr, Southborough, MA 01772, USA)
lncRNA Nuclear Enrichment Signals By Chinmay Shukla, Philipp Maass, John Rinn and colleagues: High‐throughput identification of RNA nuclear enrichment sequences. RNA function presents the same problem of deciphering ancient hieroglyphics (inscribed Rosetta stone); it functions as a hieroglyphic rather than a word based lexicon in protein coding genes. Towards decoding RNA nuclear enrichment sequences for lncRNAs we developed a massively parallel RNA assay (MPRNA) to identify functional RNA domains. We identified several RNA domains that are sufficient for nuclear localization including a C-Rich motif across domains. Scientific image by Sigrid Knemeyer, www.sigrid.knemeyer.com