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QBI Coronavirus Research Group, Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, et al. (QBI COVID-19 Research Group, San Francisco, USA; Quantitative Biosciences Institute, San Francisco, USA; University of California, San Francisco, USA; EMBL-EBI, Cambridge, UK.)
The QBI Coronavirus Research Group studied SARS-CoV-2 infection to describe and quantify a landscape of diverse phosphorylated protein outfits. These outfits are designed by kinases, that upon infection, they modulate viral entry, replication, and viral egress of infected cells. These functional roles highlight the potential of kinases as drug targets with antiviral activity. We discovered that protein fashion is not different from human fashion because protein outfits also follow trends that change with time and the infection cycle. Our analytical approach allowed us to visualize how different trends of protein outfits impact on how the cell works, for example some trends are associated with the remodelling of cell morphology and cellular death. By understanding the functions and temporal dynamics of phosphorylated protein outfits, it is possible to revert the effect of viral infection with kinase inhibitors.