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Sona Charles and Jeyakumar Natarajan (Bharathiar University)
Dilated Cardiomyopathy (DCM) is a multifactorial condition often leading to heart failure in many clinical cases. We exploited the exome and transcriptome sequencing data submitted in NCBI-SRA database to construct a high confidence scale-free regulatory network consisting of lncRNA, miRNA, mRNA and Transcription Factors (TFs). Analysis of RNA-Seq data revealed 477 differentially expressed coding transcripts and 77 lncRNAs. 268 miRNAs regulated either lncRNAs or mRNAs. Out of the 477 coding transcripts that are deregulated 82 were TFs. We identified three major hub lncRNA (XIST), miRNA (hsa-miR-195-5p) and mRNA (NOVA1) from the network. We also found putative disease associations of DEGs, miRNAs and lncRNAs in DCM with diabetes and with hypoventillation syndrome. Five highly connected modules were also identified from the network. From a high throughput dataset we have isolated a handful of probable targets that may be utilized for studying the mechanisms of DCM development and progression to heart failure. Experimental validation of the interconnected network or a subnetwork module will yield promising results in the development of therapeutic drugs against DCM.