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Rebecca Kirsch, Ole N. Jensen, Veit Schwämmle (Protein Research Group, University of Southern Denmark, Odense)
Post-translational modifications (PTMs) of histones play a fundamental role in the regulation of chromatin structure, DNA accessibility and gene expression. Individual PTMs are placed and removed by enzymes that recognize existing PTMs. This pair-wise interplay between histone PTMs, so-called crosstalk, is challenging to visualize due to the large number of PTMs and their combinations, particularly when including the abundances of single PTMs. Experimental designs with different components such as age and tissue add to this complexity. Current visualization methods are restricted to representing few levels of information contained in the datasets. Here, we map histone PTM abundances onto a PTM crosstalk landscape with coordinates that are invariant across conditions such as tissue or age, making the landscapes from different conditions compatible with each other. This improves the identification and quantitative comparison of PTM behavior and hence the interpretation of the underlying epigenetic mechanisms. Ultimately, this will enhance our understanding of gene regulation in healthy cells as well as the development of diseases such as cancer, metabolic or neurological diseases.