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Michel A. Westenberg & Jos B.T.M. Roerdink (Department of Mathematics and Computer Science, Eindhoven University of Technology, Netherlands; Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Netherlands.)
SpotXplore is a plugin for Cytoscape for visual exploration of gene expression experiments. It provides various ways to visualize gene expression from time series experiments or multiple perturbation studies in a gene network context. SpotXplore also provides two methods to detect differentially expressed subnetworks (hotspots), and a way to visualize these hotspots in the context of the whole network. This enables interactive exploration of regulatory interactions and differentially expressed (parts of) regulons.