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Ekaterina Osmekhina, Feng Jianhui, Markus Linder (Allto University, Kemistintie1, Espoo, Finland)
Super-resolution radial fluctuations (SRRF) is a computational imaging technique that enhances the resolution of fluorescence microscopy images. SRRF can improve the resolution of conventional microscopy by up to 5 times, without the need for specialized hardware or labeling techniques. In this work, we apply SRRF microscopy to study intracellular liquid liquid phase separation (LLPS) of proteins (protein condensates). LLPS is a process by which proteins and other biomolecules segregate into distinct liquid phases, forming droplets or compartments within cells. The formation of these droplets can have important consequences for cellular function, as they can serve as sites for protein localization, regulation, and signaling. Besides that, the process of LLPS plays an important role in the assembly of biological materials, such as spider silk fibers, elastin, mussel adhesive, nacre and squid beak.https://www.aalto.fi/en/department-of-bioproducts-and-biosystems/biomolecular-materials-research