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Sébastien Moretti (University of Lausanne, Lausanne, Switzerland)
Homology is a fundamental concept which allows meaningful intra & inter species comparison. In principle, we should be able to access homology information at many levels of organisation, from genes to organs. We would also like to access information about how the homologous structures have changed in evolution. At the gene level, homology is generally visualized using phylogenies. We add the possibility to visualize specific events of positive selection, both on the phylogeny and on the alignment, in Selectome: http://selectome.unil.ch/ At different levels of organisation, we map genes to organs inside a species through their expression patterns, and then present a gene family view of homologous genes expressed in homologous organs in different species. Our implementation of anatomical ontologies allows navigation among levels of detail of the anatomy, in Bgee: http://bgee.unil.ch/ We will present elements of reflection including a more intuitive navigation of the information (anatomical ontologies, anatomical & gene homologies, gene expression, developmental timing), and integra