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Gideon Dresdner, Jianjiong Gao, Blent Arman Aksoy, Ugur Dogrusoz, Benjamin Gross, S. Onur Sumer, Yichao Sun, Anders Jacobsen, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, Nikolaus Schultz (1275 York Ave, New York, NY)
The cBioPortal for Cancer Genomics provides an integrated and easy to use web resource for exploring, visualizing and analyzing multidimensional cancer genomics data. The portal reduces massive molecular profiling data from cancer tissues and cell lines to a readily understandable form as genetic, epigenetic, gene expression and proteomic events. The combination of a convenient query interface and customized data storage enables researchers to interactively explore genetic alterations across samples, genes and pathways and to link these to clinical outcomes, when available. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, and patient-centric queries. With its simple, yet powerful and flexible, interface and software programmatic access, the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries.