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Demian Keihsler (Research Institute of Molecular Pathology (IMP), Campus-Vienna-Biocenter 1, 1030 Vienna, Austria )
In collaboration with the Zuber Lab, our lab has determined the structure of human AKIRIN2 dimer bound to the 20S core particle of the proteasome using CryoEM. AKIRIN2 was shown to be essential for the nuclear import of the proteasome during mitosis. This artistic illustration shows the complex in the foreground, with the 20S CP in yellow and the AKIRIN2 homodimer in rose. In the background the nuclear pore complex dwells like a sacred gate to another dimension or a new life, representing the future of the protein in the nucleus of the emerging cell.