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Suzanne Paquette, Kalle Leinonen, William Longabaugh (Institute for Systems Biology, Seattle WA USA)
BioTapestry is a well-established tool for building, visualizing, and sharing models of gene regulatory networks (GRNs), with particular emphasis on the GRNs that drive development. Recent work has focused on migrating BioTapestry from a pure Java application to a dual-mode architecture that can support both the popular current desktop version (using Java2D) as well as a new browser-based web application (using HTML5 Canvas). We have also applied lessons learned from developing the new companion BioFabric network visualization tool to enhance BioTapestry’s presentation and performance on large directed networks. BioTapestry's "circuit trace" links are highly scalable, and thus one can automatically create rational, understandable, and highly organized presentations of large networks containing thousands of nodes.