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Margot Riggi (University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva, Switzerland)
Cover proposition for the article of M. Mendel & al (Mol Cell, 2018). Internal modification of RNAs with N6-methyladenosine is a highly conserved means of gene expression control. While the METTL3/14 heterodimer adds this mark on thousands of transcripts in a single-stranded context, METTL16 selects for methylation-structured RNAs where the critical adenosine is present in a bulge. Mouse 16-cell embryos lacking Mettl16 display reduced mRNA levels of its methylation target, the SAM synthetase Mat2a. The consequence is massive transcriptome dysregulation in ∼64-cell blastocysts that are unfit for further development.