Thumbnails:
List:
Year:
Category:
Session:
Poster:
Getting poster data...
Nuno Saraiva-Agostinho, Nuno Barbosa-Morais (Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisboa, Portugal)
Alternative splicing (AS) generates functionally distinct transcripts and is involved in multiple cellular processes, with its dysregulation being linked to diverse pathologies. The advent of next-generation sequencing has enabled genome-wide AS studies. To assist in performing such studies, we developed psichomics, an R package with an intuitive graphical interface for AS quantification and integrative analyses of AS and gene expression from large transcriptomic and user-provided RNA-seq datasets. psichomics employs efficient visualisation tools that assist the user in performing survival, dimensionality reduction, and median- and variance-based differential AS and gene expression analyses in large datasets. These tools make use of Shiny and JavaScript plotting libraries that are interactive (e.g. zooming and displaying contextual information when hovering data), flexible (allowing to render personalised plots, such as survival, transcript and protein domain plots) and responsive. psichomics is publicly available in Bioconductor at https://bioconductor.org/packages/psichomics, along with tutorials on its graphical and command-line interfaces.