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John "Scooter" Morris, Thomas Ferrin (University of California San Fancisco, San Francisco, CA, USA)
Established in 1970, the Resource for Biocomputing, Visualization, and Informatics (RBVI) develops software and Web-based resources for the visualization and analysis of molecular structure at scales ranging from the atomic to the supramolecular. Over the last five years, we have become increasingly involved in the analysis and visualization of those molecular structures within the biological context that can be represented by biological networks. We use Cytoscape as a tool to visualize those networks and expand the capabilities of Cytoscape with a set of plugins that provide tools for enhanced visualization and analysis. Some of these tools include structureViz, a plugin that links Cytoscape and UCSF Chimera; clusterMaker, a plugin providing a number of clustering algorithms and visualizations; chemViz, that provides small molecule visualization and analysis capabilities for Cytoscape; and metaNodePlugin, which when used in conjunction with the nodeCharts plugin provides the ability to collapse groups of nodes and visualize the attributes of individual nodes as pie, bar, or line charts on the collapsed node (metanode).