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Paraskevi Vlachou (https://www.dkfz.de/en/immundiversitaet/index.php)
Vaccination strategies intend to imitate the endogenous ability of the immune system to remember the antigens it has been in contact with, leading to faster and optimized immune response. B cells, the humoral part of adaptive immunity, perform a vital role in the defense against pathogens, by producing antibody-secreting plasma cells and memory B cells. An optimal immune response results in high, neutralizing antibody titers that persist in the body and long-lasting functional memory. The complexity of such a fine process makes it difficult to study let alone reproduce under the means of vaccination. Papavasiliou Lab proposes a novel yet unconventional vaccine platform. By exploiting the natural antigenicity of the T. brucei’s coat glycoproteins and the functional memory that such a platform elicits, they south to assemble the profile of successful immunizations, by studying the subsequent memory B cell and long-lived plasma cell populations. In this study, we employed single-cell RNA sequencing approaches to investigate memory B cells, uncover the “true” memory B cell subpopulations, and elucidate the transcriptional and phenotypical characteristics of functional memory.