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Frank Siedler, Kristina A. Ganzinger, Petra Schwille (MPI of Biochemistry, Martinsried, Germany; AMOLF, Amsterdam, The Netherlands; MPI of Biochemistry, Martinsried, Germany)
“Microfluidics” describes the control of fluids geometrically constrained to typically sub-millimeter sized cavities. As a consequence of the small dimensions, flows are usually strictly laminar which allows for fascinating applications. The “droplet-based” microfluidics is a branch in which discrete volumes of fluids in immiscible phases are handled. When lipids are applied to this in smartly chosen geometries, even vesicles can be formed on-chip and subsequently be analyzed for their behavior. But how to explain the design and functionality of the tiny devices to non-specialists? Here magnified models are a perfect tool. The technology best suited for producing such educational models is Objet or Multijet due to its full-color capability. Developed according to the 2D inkjet technology where jets of ink droplets are combined on paper to yield a full color image, this translates in 3D to jets of colored photo-curable resin droplets. Applied layer-by-layer a 3D structure can be built. As an example for the application of the procedure educational models of a microfluidics device are shown which is used to examine protein pattern changes in a bottom-up synthetic biology approach.