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Pascale Marill, Mo Rahman, Onno Faber, Otavio Good (GeneDrop Inc, San Francisco, USA)
Proteins are life's building blocks with structure and function linked intricately. New computational tools are creating novel proteins, leading to an explosive growth in protein design. Dalton is a cross-platform desktop application for protein design and visualization with powerful features to explore the boundless possibilities of the protein universe.This presentation showcases Dalton's capabilities for designing and visualizing custom proteins, highlighting its user-friendly interface and tools for designing and editing protein structures. It demonstrates how Dalton works with ColabFold to design proteins with specific features, analyzes predicted structures, and refine designs. Dalton also integrates with the KEGG API and KGML, visualizing metabolic pathways and protein-protein interaction networks. It can design proteins to interact with enzymes or pathways, offering potential for designing new enzymes with specific metabolic functions. Overall, Dalton is a valuable asset for researchers and designers, providing powerful tools, a user-friendly interface, and flexible design features for exploring the complex world of protein design.