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Hieu T. Nim, Mirana Ramialison (Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, Victoria, Australia; Murdoch Children’s Research Institute, Flemington Road, Parkville, Victoria, Australia)
The heart is a complex organ composed of distinct anatomical structures (e.g. myocardium, septum, vessels and pace maker) characterised by different cell types. Together, these structures ensure proper cardiac function and any impairment in the integrity of these structures will lead to heart disease. The formation of these distinct cardiac structures is governed by a cardiac-specific gene regulatory network which controls the spatio-temporal expression of genes in the different heart compartments. Little is known about the genes that compose this network, and more particularly, gene expression patterns of a limited number of genes have been investigated so far in the mammalian adult heart. To uncover this information in an unbiased manner, we have performed gene expression profiling by RNA-sequencing in 18 different compartments of the adult mouse heart. We have designed a computational framework based on the Unity game engine to visualise digital gene expression obtained by RNA-sequencing on the three-dimensional heart model. Furthermore, we provide a freely available searchable web interface (http://3d-cardiomics.erc.monash.edu/) which allows synexpression analysis and differen