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Luis Lopes (DEMCON | nymus3D, Institutenweg 25, 7521PH Enschede, the Netherlands)
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases and cancer. Using small intestinal and lung organoids, here we show that apicomplexan parasite Cryptosporidium parvum can infect epithelial organoids derived from human small intestine and lung. The parasite propagates within the organoids and completes its full complex life cycle (asexual and sexual) within the organoid lumen within 120 -168 hrs. https://www.nature.com/articles/s41564-018-0177-8 This image is part of a two minute animation created for the Hubrecht Institute: https://nymus3d.nl/en/portfolio/project/cryptosporidium For AR exhibit