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Bernard de Bono (EMBL-EBI, Cambridge, United Kingdom)
Improving the interoperability of data and models from different scales and systems is a challenging goal for biology, and the development of appropriate visualisation tools is essential to achieve this aim. In this presentation, we shall discuss our ongoing efforts to integrate and visualise (i) physiological relationships between anatomical locations and (ii) molecular data associated with anatomy. Specifically, in collaboration with the Virtual Physiological Human (VPH: http://www.vph-noe.eu), SBML, SBGN, CellML and ArrayExpress projects, we are building a multi-scale anatomical framework for the integration of anatomy-linked (i) gene expression data and (ii) physiology-based human models (i.e network of variables each depicting physical properties such as pressure, compliance, electrophysiological activity, etc). The sample diagram, showing anatomically-correct vascular relationships (vessel segments are numbered) between key abdominal viscera, is produced by the associated visualisation component of our API toolkit that draws upon relationships in the Foundational Model of Anatomy (FMA). This tool infers the functional connectivity between