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Anil S Thanki, Nicola Soranzo, Robert P. Davey (The Genome Analysis Centre, Norwich Research Park, Norwich, UK)
The study of homologous genes enables the tracing back of conserved functionality through evolution and finds relationships among species. There are many tools to visualise syntenic information among species, representing gene order and orientation, but they do not provide details about structural diversity within genes and between gene families. Aequatus-vis is a new open-source rendering library for web services to visualise homologous genes through alignment and phylogenetic analysis. It is developed in JavaScript using standard formats in order to provide a portable and easy-to-implement web platform to visualise and explore complex relationships among genes from various species. The Aequatus Browser is a client-server Java application which uses aequatus-vis to visualise homologous genes on the web. It processes data directly from the Ensembl Compara and Core schema databases and visualises the comparison. We are extending the Aequatus Browser to retrieve data using the Ensembl REST API and visualise them. We are also developing Galaxy tools and workflows to replicate the full Ensembl GeneTree pipeline and integrate the aequatus-vis visualisation in the Galaxy user interface.