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Duygu Koldere Vilain (Designosome Scientific Visuals)
In Alzheimer’s disease, neurons in the brain lose their ability to regulate calcium properly, which contributes to their dysfunction and decline. Princen et al. (2024, Science) discovered a way to restore this balance using a compound—a “molecular glue” that stabilizes septins, preventing calcium overload, reducing the buildup of toxic proteins, and improving brain function in Alzheimer’s disease models. This illustration brings their findings to life through the Japanese art of Kintsugi—repairing broken pottery with gold. A shattered ceramic brain symbolizes the damage caused by Alzheimer’s, while intricate patterns, inspired by Cajal’s neuron drawings, weave through the surface. The golden “molecular glue” holding the pieces together represents a potential therapeutic approach, offering a visual metaphor for healing and restoring function in the brain.