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Sungeun (Kristina) Song, Gabrielle Deschamps-Francoeur, Sherif Abou-Elela, Michelle S. Scott (Université de Sherbrooke, Sherbrooke, Canada)
Box C/D small nucleolar RNAs (snoRNAs) are noncoding RNAs known to guide 2’-O-ribose methylation during ribosome biogenesis. Their canonical functions are carried out by forming ribonucleoprotein (snoRNP) complexes with four RNA-binding proteins (RBPs). Additional roles have been suggested for box C/D snoRNAs, including the regulation of alternative splicing and the stability of protein-coding transcripts by interacting with noncanonical targets through various binding mechanisms. Both individually validated and high-throughput approaches have revealed that diverse RBPs can bind snoRNAs and that snoRNAs interact with a wide range of noncanonical target biotypes with a large number of targets corresponding to protein-coding RNAs. To study the extent of noncanonical snoRNA functions in relation to RBPs, we introduce the snoRNA-RBP interactome involving various types of snoRNA and RBP interactions represented as edges, while the nodes correspond to box C/D snoRNAs, RBPs and their protein-coding targets. The snoRNA-RBP interaction network serves as a starting point for defining the snoRNA-RBP relationship and its effect on the gene expression regulation of protein-coding targets.