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Jakub Vašíček, Dafni Skiadopoulou, Ksenia G. Kuznetsova, Stefan Johansson1, Pål R. Njølstad, Stefan Bruckner, Lukas Käll, Marc Vaudel (Klinisk institutt 2, Universitetet i Bergen, Laboratoriebygget (administrasjon/ekspedisjon i 8 etasje), Haukeland Universitetssykehus, Jonas Lies veg 87, 5021 Bergen, Norway)
Our understanding of the process of gene expression is driving the progress in precision medicine, allowing us to tailor treatments to individual profiles of patients and populations. Mass spectrometry (MS/MS) based proteomics is improving our ability to identify the consequences of genetic variation in the proteome thanks to its ability to cover a wide range of peptides contained in a biological sample. This gives the opportunity to explore the proteome and identify rare peptide sequences, i.e., predicted with a lower frequency of occurrence than canonical sequences. This year, our group will be launching a web-based interactive resource charting the influence of genetic variation in the proteome. In this poster, I present the initial design of this interface, and discuss the challenge of mapping peptides identified by MS/MS back to their genetic origin, while keeping the detailed information on quality control available to the user. Our resource holds the promise to be useful to medical researchers, biologists and bioinformaticians working with mass spectrometry alike, as it provides multiple angles to view proteogenomics data.