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Andrew Waterhouse, Janani Durairaj, Torsten Schwede, Joana Pereira (SIB, University of Basel, Switzerland)
The “Protein Universe” refers to the collection of all possible proteins, in which functionally characterised proteins correspond to stars, protein families to galaxies, and protein superfamilies to clusters of galaxies, surrounded by all those sequences which are evolutionary related but not as yet functionally characterised or sampled by nature. In the Protein Atlas, entries are represented with coordinates dictated by their similarity to all proteins in UniProtKB. This puts them in context, highlighting previously unknown evolutionary relationships that can help guide biocuration, protein family classification, and protein function prediction and annotation. Here, we present the first iteration of the Protein Universe, made possible with the GPU-accelerated Force layout of Cosmograph App in combination with Mol* toolkit.