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Peter Ilgen, Till Stephan, Stefan Jakobs (MPI for biophysical Chemistry, Am Fassberg 11, 37077 Göttingen)
The image shows the different levels of complexity that determine mitochondrial morphology: The left panel shows a STED super-resolution microscopy image showing the distribution and localization of two of the major proteins responsible for shaping the mitochondrial inner membrane: ATP synthase in red and Mic60 in cyan. Their interaction with other proteins determines not only the overall structure of the cristae, as seen in the center with a 3D reconstruction of FIB-SEM data, but also the intricate structures of cristae junctions and their distribution and localization within a mitochondrion, as seen here on the right in the 3D reconstruction of electron tomography data. Only the combined power of these three imaging techniques can give us a deeper insight into the cell's "powerhouse": the mitochondrion.