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Fanny Georgi (Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland)
Infectious diseases are a major health threat to humans and amongst the most frequent causes of death worldwide. Infections of the lower respiratory tract are a leading cause of death in patients with respiratory impairment. Human adenovirus infects, amongst other tissues, the lower respiratory tract. Although this virus has been intensely studied over decades and is widely used as a gene delivery vehicle and anti-cancer agent, no efficient therapeutics against adenovirus are available to date. We employ high-throughput time-lapse imaging, and screen for therapeutics that alter or inhibit viral spread in cellular monolayers. Infection phenotypes are scored with Plaque2.0 (http://plaque2.github.io/), a software that automatically quantifies a range of infection phenotypes, generating multiparametric data sets. The representation of multi-dimensional data in comprehensive figures proofed to be challenging. Here, we show the color-coded progression of Human Adenovirus viral spread across a cellular monolayer.