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Ritik Sinha (IIIT Allahabad)
A Copy Number Variant is a structural variant in the human genome that may result in loss or gain of a genomic sequence. These insertions, deletions, inversions, and duplications result in changes in the physical arrangement of genes on chromosomes (Clancy, S., 2008, Copy number variation. Nature Education). Several studies have linked it to metastatic breast cancer. If the variation is in the metastatic promoter gene then the CNV is associated with an aggressive tumour that is likely to metastasise to the bones and liver. Gains in CTAGE5, NDUFC2, EIF4EBP1, and PSCA genes and their expression may aid in early diagnosis of metastatic breast carcinoma and have potential as therapeutic targets (Behring et. al. 2018).https://www.researchgate.net/project/Genomics-of-metastatic-breast-cancer