Getting poster data...
Nicola Lopizzo, Veronica Begni, Sarah Tosato, Simona Tomassi, Marco Andrea Riva, Carmine Maria Pariante, Annamaria Cattaneo (IRCCS Fatebenefratelli San Giovanni di Dio, Brescia; Response variability to Psychotropic, Paris, France; University of Milan, Milan, Italy; University of Verona, Verona, Italy; King’s College, London)Exposures to stressful life events are known to affect mood and behavior and to increase the vulnerability for several kind of stress related mental disorders. Alterations in the Hypothalamic-Pituitary-Adrenal (HPA) axis and in the immune response as well as telomere biology might represent possible mechanisms linking stressful events with disease risk. In this study, we performed transcriptomic analyses in the blood of control subjects characterized for recent stressful life events. CEL files were imported into Partek Genomics Suite 6.6 for data visualization, quality control and statistical analyses. Ingenuity Pathway Analyses Software was then used to identify regulation in molecular pathways and networks. The exposure to stressful life events caused the modulation of 297 genes (p-value< 0.05) involved in several biological systems. We have also investigated the telomere length in the DNA samples of the same subjects. Our results indicate that stress can cause alterations in immune systems and reduction in telomere length and that these mechanisms may render the subjects more vulnerable to develop stress related psychopathology.