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Matthew Huska (MDC Berlin, Berlin, Germany)
BiasViz 2 is a web browser applet designed to give an interactive graphical overview of multiple sequence alignments quickly and easily. Specifically, BiasViz was created to aid in the visualization of composition biased regions in protein sequences, which may act as linkers between protein domains while conferring specific binding to various molecules. A sliding window is used to highlight biased regions, and the size of the window and amino acids of interest can be manipulated in real time to aid in quickly identifiying and clearly defining regions with compositional bias. Recently new features have been added to make the application useful beyond the analysis of biased regions. Multiple tracks can now be loaded simultaneously to allow the visualization of multiple types of data in the context of the multiple sequence alignment, including secondary structure predictions from JPred as well as generic tracks that can be defined in a simple tabular format.