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Kate Patterson and Susan Clark (Garvan Institute of Medical Research, 384 Victoria Street Darlinghurst, NSW, Australia, 2010)
Epigenetics refers to heritable characteristics that are not determined by the DNA code. It is now clear that epigenetics is involved in initiation and development of various diseases. Visual tools related to genetics have been refined over time, with the DNA molecule being relatively simple and immediately recognizable. This is a challenge yet to be resolved for epigenetics, due inpart to its inherent complexity. The multiple layers of the epigenome, are comprised of proteins and protein modifications that can interact with each other, the genome and also the environment to ultimately control gene expression. The aim of this work is to increase awareness and understanding of epigenetics using visual tools. The recent initiation of the NIH Roadmap and International Human Epigenome Consortium, gives this particular significance. The concept for visualization involves navigating through the epigenome layers, deep into the organization of chromatin, histone modifications, DNA methylation and ncRNAs. Dissemination of visualization resources via scientific presentations, web and printed educational materials will help build awareness and further understanding of epigenetic complexities