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Sumit Bala, Ambarnil Ghosh, Subhra Pradhan (Independant Researcher, Bangalore, India; University College Dublin, Dublin, Ireland; Independant Researcher, Dublin, Ireland)
High rate of mutations and structural flexibilities in viral proteins make them resistant to host immune system defense and indestructible by currently exiting antiviral strategies and vaccines. Finding conserved regions with various chemical and biological properties from viral proteins is an important area of research for developing antiviral strategies, though assigning those regions is not a trivial work. In the current research work, authors developed a web application for thorough mining of the surface properties of viral proteins in combination with immunogenic and evolutionary feature of viral proteins. Five parameters or surface characteristics considered for this work are: sequence stretch variability using 20-dimensional algorithm, predicted solvent accessibility information, predicted B-Cell epitopic potential, predicted T-Cell epitopic potential and co-evolution properties of the residues. Currently the database contains total 9 proteins from 2 viruses and authors have pipeline ready to add other pathogenic viruses to this exploration. Web server address is: http://www.protsegvar.com